Use of fumaric acid esters in psoriasis
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منابع مشابه
Use of fumaric acid esters in psoriasis.
Fumaric acid esters (FAE) are chemical compounds derived from the unsaturated dicarbonic acid fumaric acid. The usage of FAEs in treatment of psoriasis was introduced in the late 1950's. In the 1980s more standardized oral preparations of FAEs were developed containing dimethylfumarate (DMF) and salts of monoethylfumarate (MEF) as main compounds. In 1994, Fumaderm an enteric-coated tablet conta...
متن کاملFumaric acid esters in the management of psoriasis
Fumaric acid esters (FAE) are small molecules with immunomodulating, anti-inflammatory, and anti-oxidative effects. FAE were introduced as a systemic psoriasis treatment in 1959 and empirically developed further between 1970 and 1990 in Germany, Switzerland, and the Netherlands. The development of FAE as psoriasis treatment did not follow the traditional drug development phases. Nonetheless, in...
متن کاملReview of the Use of Fumaric Acid Esters in Dermatology
Background: Fumaric acid esters (FAE) have been used as a drug since 1959. The therapeutic preparation containing FAE has been one of the prominent drugs used for the systemic treatment of psoriasis since 1994 in Germany. FAE have been used in the treatment of sarcoidosis, granuloma annulare, necrobiosis lipoidica, cheilitis granulomatosa, annular elastotic giant cell granuloma, malignant melan...
متن کاملTreatment of severe psoriasis with fumaric acid esters: scienti®c background and guidelines for therapeutic use U.MROWIETZ, E.CHRISTOPHERS AND P.ALTMEYER* FOR THE GERMAN FUMARIC ACID ESTER CONSENSUS CONFERENCE
Fumaric acid ester (FAE) therapy has proved to be safe and effective in patients with severe psoriasis vulgaris. This treatment was introduced nearly 30 years ago, but is only now gaining renewed interest among dermatologists. FAE therapy is licensed in Germany and registration is pending in many European countries. Multicentre trials have con®rmed the bene®cial effect of FAE in psoriasis and h...
متن کاملIn vitro pharmacokinetics of anti-psoriatic fumaric acid esters
BACKGROUND Psoriasis is a chronic inflammatory skin disease that can be successfully treated with a mixture of fumaric acid esters (FAE) formulated as enteric-coated tablets for oral use. These tablets consist of dimethylfumarate (DMF) and salts of monoethylfumarate (MEF) and its main bioactive metabolite is monomethylfumarate (MMF). Little is known about the pharmacokinetics of these FAE. The ...
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ژورنال
عنوان ژورنال: Indian Journal of Dermatology, Venereology and Leprology
سال: 2007
ISSN: 0378-6323
DOI: 10.4103/0378-6323.31908